SWI2/SNF2

**Semantic type:** Amino Acid, Peptide, or Protein|Biologically Active Substance

**Definition:** Nuclear SWI2/SNF2 (SNF2/RAD54 Helicase Family) is a 1703-aa, 194-kD general RNA polymerase II transcription regulator component of the SWI/SNF nucleosome/chromatin remodeling complex involved in global transcriptional activation of induced gene expression and coordinate regulation of phospholipid synthesis. This complex alters chromatin structure to facilitate binding of gene-specific transcription factors. Containing a bromodomain domain and three AT Hook DNA-binding repeats, SWI2/SNF2 exhibits strong similarity to Drosophila brahma. (from Swiss-Prot, and NCI)

**Synonyms:** - Mating Type Switch 2/Sucrose Nonfermenting 2 - Regulatory Protein GAM1 - Regulatory Protein SWI2 - SWI/SNF Complex Component SNF2 - Snf2p - Swi2p - Transcription Factor TYE3 - Transcription Regulatory Protein SNF2