Stage M Childhood Neuroblastoma by Toronto Guidelines v2

**Semantic type:** Neoplastic Process

**Definition:** Distant metastatic disease (i.e., not contiguous with the primary tumor) except as defined for stage MS. Nonregional (distant) lymph node involvement is metastatic disease. However, an upper abdominal tumor with enlarged lower mediastinal nodes or a pelvic tumor with inguinal lymph node involvement is considered locoregional disease. Ascites and/or a pleural effusion, even with malignant cells, do not constitute metastatic disease unless they are remote from the body compartment of the primary tumor. (Childhood cancer staging for population registries according to the Toronto Childhood Cancer Stage Guidelines - Version 2. Cancer Council Queensland and Cancer Australia: Brisbane, Australia; 2021.)

**Synonyms:** - Neuroblastoma Stage M - Stage M Childhood Neuroblastoma by Toronto Guidelines v2, Tier 2 - Stage M Pediatric Neuroblastoma by Toronto Guidelines v2 - Stage M Pediatric Neuroblastoma by Toronto Guidelines v2, Tier 2