Sipuleucel-T

**Semantic type:** Cell|Immunologic Factor|Pharmacologic Substance

**Definition:** A cell-based vaccine composed of autologous antigen-presenting peripheral blood mononuclear cells (enriched for a dendritic cell fraction) that have been exposed to a recombinant protein consisting of granulocyte-macrophage colony-stimulating factor (GM-CSF) fused to prostatic-acid phosphatase (PAP), a protein expressed by prostate cancer cells. Upon administration, the vaccine may stimulate an antitumor T-cell response against tumor cells expressing PAP. (NCI05)

**Synonyms:** - APC 8015 - APC-8015 - APC8015 - APC8015 - APC8015 Vaccine - PA2024 (PAP/GM-CSF)-Loaded Dendritic Cell Vaccine - Provenge - Provenge - SIPULEUCEL-T - SipT - sipuleucel-T - sipuleucel-t