Androgen Receptor Degrader AC176

**Semantic type:** Pharmacologic Substance

**Definition:** An orally bioavailable androgen receptor (AR) chimeric degrader, with potential antineoplastic activity. Upon oral administration, AR degrader AC176 targets and degrades AR, thereby preventing AR-mediated signaling and inhibiting the proliferation of AR-overexpressing tumor cells. AR, a hormone-regulated transcription factor, plays a key role in tumor cell proliferation in castration-resistant prostate cancer (CRPC).

**Synonyms:** - AC 176 - AC-176 - AC0176 - AC176 - AR Degrader AC176