D3-Creatine Dilution

**Semantic type:** Diagnostic Procedure

**Definition:** A procedure that measures the excretion of creatinine (Crn) and D3-creatinine (D3Crn) in the urine to determine the total body creatine pool and thus total body skeletal muscle mass. The individual being tested ingests deuterium-labeled creatine and several days later provides a fasting, morning urine sample. D-3 creatinine, unlabeled creatinine, and creatine are then measured using high-performance liquid chromatography (HPLC) and tandem mass spectroscopy (MS/MS).

**Synonyms:** - D3-Cr Dilution - D3Cr Dilution - Deuterated Creatine Dilution