t(1;17)(q42.3;q21.2)

**Semantic type:** Cell or Molecular Dysfunction

**Definition:** A cytogenetic abnormality that refers to the translocation of chromosome 1q42.3 with chromosome 17q21.2. It results in the formation of IRF2BP2-RARA fusion gene. It is associated with the development of acute myeloid leukemia with t(1;17)(q42.3;q21.2); IRF2BP2-RARA.