International Neuroblastoma Response Criteria, Brodeur 1993

**Semantic type:** Intellectual Product

**Definition:** A revision of the International Neuroblastoma Staging System (INSS) and International Neuroblastoma Response Criteria (INRC). The revisions included redefinition of the midline, restrictions on age and bone marrow involvement for stage 4S, and the recommendation that meta-iodobenzylguanidine (MIBG) scanning be implemented for evaluating the extent of disease. The biologic features that were deemed important to evaluate included serum ferritin, neuron-specific enolase (NSE), and lactic dehydrogenase (LDH); tumor histology; tumor-cell DNA content; assessment of N-Myc copy number; assessment of chromosome 1p deletion by cytogenetic or molecular methods; and high affinity nerve growth factor receptor (Trk-A) expression.

**Synonyms:** - INRC 1993 - INRC, Brodeur 1993 - INRC, Brodeur 1993 - International Neuroblastoma Response Criteria 1993