TRAP Complex

**Semantic type:** Amino Acid, Peptide, or Protein

**Definition:** The human thyroid hormone receptor-associated protein (TRAP)-Mediator complex was originally identified as a large multimeric complex that copurifies with the thyroid hormone receptor (TR) from HeLa cells and markedly enhances TR-mediated transcription in vitro. More recent studies have implicated TRAP-Mediator as a coactivator for a broad range of nuclear hormone receptors as well as other classes of transcriptional activators. TRAP-Mediator may play an important coregulatory role in androgen receptor-mediated gene expression. (from J Biol Chem. 2002;277:42852-8)

**Synonyms:** - TRAP Mediator - TRAP Mediator Complex - TRAP/Mediator Complex - Thyroid Hormone Receptor-Associated Protein Complex