Zongertinib

**Semantic type:** Pharmacologic Substance

**Definition:** An orally bioavailable inhibitor of the receptor tyrosine kinase human epidermal growth factor receptor 2 (HER2; ErbB2; HER-2), with potential antineoplastic activity. Upon oral administration, zongertinib covalently binds to and inhibits the activity of both wild-type and HER2 mutants, including HER2 mutants with exon 20 insertion (ex20ins) mutations. This prevents HER2-mediated signaling and may lead to cell death in HER2-expressing tumor cells. HER2, a receptor tyrosine kinase overexpressed on a variety of tumor cell types, plays an important role in tumor cell proliferation and tumor vascularization.

**Synonyms:** - BI 1810631 - BI-1810631 - BI1810631 - HER-2 Inhibitor BI 1810631 - HER2 Inhibitor BI 1810631 - Hernexeos - ZONGERTINIB