Gallium Ga 68 Rofapitide Tetraxetan

**Semantic type:** Indicator, Reagent, or Diagnostic Aid|Pharmacologic Substance

**Definition:** A radioconjugate composed of rofapitide tetraxetan, a fibroblast activation protein (FAP)-targeted peptide, attached to a linker and tetraazacyclododecane tetraacetic acid chelator, and conjugated to the radioisotope gallium Ga 68, with potential use as a tracer for FAP-expressing cancer-associated fibroblasts (CAFs) during positron emission tomography (PET). Upon administration of gallium Ga 68 rofapitide tetraxetan, rofapitide tetraxetan targets and binds to FAP-expressing CAFs. Upon binding, FAP-expressing cells can be detected during PET imaging. FAP, a cell surface protein, is overexpressed on CAFs in the tumor microenvironment (TME).

**Synonyms:** - 68Ga-FAP-2286 - GALLIUM (68GA) ROFAPITIDE TETRAXETAN - Gallium Ga 68 FAP-2286 - Gallium-68 labelled FAP-2286 - Gallium-68-FAP-2286