Osivelotor

**Semantic type:** Pharmacologic Substance

**Definition:** An orally bioavailable sickle cell hemoglobin S (HbS) stabilizer and polymerization inhibitor, with potential use in the treatment of sickle cell disease (SCD). Upon oral administration, osivelotor targets and covalently binds to HbS. This increases the affinity of Hb for oxygen and stabilizes it in its oxygenated, oxy-hemoglobin (oxyHb) state. This prevents HbS polymerization and HbS aggregation, which reduces red blood cell (RBC) sickling, improves RBC deformability, reduces whole blood viscosity, and decreases hemolytic anemia.

**Synonyms:** - GBT 021601 - GBT 601 - GBT-021601 - GBT-601 - GBT021601 - GBT601 - OSIVELOTOR - PF 07940367 - PF-07940367 - PF07940367