Zavondemstat

**Semantic type:** Pharmacologic Substance

**Definition:** An orally bioavailable, small-molecule, pan inhibitor of histone lysine (K) demethylase 4 (KDM4), with potential antineoplastic activity. Upon oral administration, zavondemstat specifically targets, binds to and inhibits the catalytic activity of all members of the KDM4 family of proteins. This may prevent KDM4-mediated signaling, epigenetic dysregulation and inhibit the proliferation of tumor cells. The KDM4 family of histone demethylases is frequently upregulated in a variety of cancers and plays an important role in nuclear functions including the regulation of transcription, cell cycle, and DNA replication and repair.

**Synonyms:** - Histone Lysine Demethylase 4 Inhibitor TACH101 - KDM4 Inhibitor TACH101 - QC 8222 - QC-8222 - QC8222 - TACH 101 - TACH-101 - TACH101 - ZAVONDEMSTAT