TCF4/HLF Fusion Gene

**Semantic type:** Gene or Genome

**Definition:** A fusion gene that results from a chromosomal rearrangement with breakpoints in the vicinity of 18q21.2 and 17q22 that fuses exon 15 of the TCF4 gene upstream of exon 3 of the HLF gene. This rare rearrangement is associated with childhood pre-B cell acute lymphoblastic leukemia.

**Synonyms:** - TCF4-HLF Fusion Gene - TCF4::HLF Fusion Gene