Anti-TSPAN8/Anti-CD3 Bispecific Antibody ASP2074

**Semantic type:** Amino Acid, Peptide, or Protein|Immunologic Factor|Pharmacologic Substance

**Definition:** A bispecific antibody directed against both the tumor-associated antigen (TAA) tetraspanin-8 (TSPAN8) and the T-cell surface antigen CD3, with potential immunostimulating and antineoplastic activities. Upon administration, anti-TSPAN8/anti-CD3 bispecific antibody ASP2074 binds to both TSPAN8 expressed on tumor cells and CD3 expressed on T-cells. This results in the cross-linking of T-cells and tumor cells, and induces a cytotoxic T-lymphocyte (CTL) response against TSPAN8-expressing tumor cells. TSPAN8, a member of the tetraspanin superfamily of proteins, is overexpressed on a variety of tumor cells and associated with tumor cell growth, angiogenesis, invasion and metastasis.

**Synonyms:** - ASP 2074 - ASP-2074 - ASP2074 - Anti-TSPAN8/CD3 Bispecific Antibody ASP2074 - Bispecific Antibody ASP2074 - TSPAN8 x CD3 Bispecific Antibody ASP2074