Anti-B7-H4/Anti-CD3 Bispecific Antibody GEN1047

**Semantic type:** Amino Acid, Peptide, or Protein|Immunologic Factor|Pharmacologic Substance

**Definition:** A bispecific monoclonal antibody against both B7-H4 (V-set domain-containing T-cell activation inhibitor 1; VTCN1; B7x; B7S1) and T-cell surface antigen CD3, with potential immunostimulating and antineoplastic activities. Upon administration, anti-B7-H4/anti-CD3 bispecific antibody GEN1047 targets and binds to both B7-H4 on the surface of tumor cells and CD3 on T-cells. This results in the cross-linking of tumor cells and T-cells, and induces a cytotoxic T-lymphocyte (CTL) response against B7-H4-expressing tumor cells. B7-H4, a member of the B7 family of immune modulators, is upregulated in a variety of tumor cell types and negatively regulates T-cell immune responses.

**Synonyms:** - DuoBody-CD3xB7H4 GEN1047 - GEN 1047 - GEN-1047 - GEN1047