Allogeneic Gene-modified Gamma Delta T-cells

**Semantic type:** Cell|Pharmacologic Substance

**Definition:** A preparation of genetically modified allogeneic gamma delta T-lymphocytes, with potential immunomodulating and antineoplastic activities. Upon administration, the allogeneic gene-modified gamma delta T-cells secrete interferon-gamma (IFN-g) and exert direct killing of tumor cells. In addition, these cells activate the immune system to exert a cytotoxic T-lymphocyte (CTL) response against tumor cells. Gamma delta T-lymphocytes play a key role in the activation of the immune system and do not require major histocompatibility complex (MHC)-mediated antigen presentation to exert their cytotoxic effect. The genetic modification of the allogeneic gene-modified gamma delta T-cells may confer resistance to alkylating chemotherapeutic agents including temozolomide and allow the use of the gamma delta T-cells as an adjunct to these agents.

**Synonyms:** - Allogeneic Genetically Modified Gamma-delta T Cells