Cabotegravir/Rilpivirine

**Semantic type:** Pharmacologic Substance

**Definition:** An extended-release injectable formulation of cabotegravir, a human immunodeficiency virus type 1 (HIV-1) integrase strand transfer inhibitor (INSTI), and rilpivirine, a non-nucleoside reverse transcriptase (RT) inhibitor (NNRTI), that may be used to treat HIV infection. Upon intramuscular administration of cabotegravir/rilpivirine, cabotegravir binds to and blocks the active site of HIV integrase, an HIV-1 coded enzyme that is necessary for viral replication, thereby inhibiting its activity. Inhibition of integrase prevents the integration of HIV-1 DNA into host genomic DNA. Rilpivirine binds to HIV RT, thereby blocking RNA and DNA-dependent DNA polymerase activities including viral replication, thereby further preventing HIV-1 replication.

**Synonyms:** - Cabenuva - Cabenuva - Vocabria/Rekambys