Autologous Anti-TM4SF1 CAR-T Cells

**Semantic type:** Cell|Pharmacologic Substance

**Definition:** A preparation of autologous T-lymphocytes that have been genetically engineered to express a chimeric antigen receptor (CAR) specific for the tumor-associated antigen (TAA) transmembrane 4 L six family member 1 (TM4SF1) and containing a safety/kill switch composed of a truncated form of the human epidermal growth factor receptor (ErbB1t; EGFRt HER1t), with potential immunostimulating and antineoplastic activities. Upon administration, the autologous anti-TM4SF1 CAR-T cells specifically recognize and bind to TM4SF1-expressing tumor cells, resulting in tumor cell lysis. TM4SF1 plays a key role in the regulation of cell development, activation, growth and motility, and is overexpressed by a variety of tumor cells.

**Synonyms:** - Anti-TM4SF1-CAR-expressing Autologous T-cells - Autologous TM4SF1-CAR T-cells - Autologous TM4SF1-positive CAR T-cells - Autologous TM4SF1-positive CAR-T Cells - TM4SF1-CAR-expressing Autologous T-cells