NHS-POx-based Hemostatic Sealant Patch

**Semantic type:** Pharmacologic Substance

**Definition:** A sterile resorbable hemostatic sealing patch composed of porcine gelatin fiber-based carrier loaded with N-hydroxy-succinimide polyoxazoline (NHS-POx) polymer and nucleophilically activated polyoxazoline (NU-POx) granulate, with potential hemostatic activity. Upon application on the wound tissue, the coagulation cascade is started. A matrix of platelet aggregation is formed, and a fibrin clot is formed in the gelatin fibers. This combines with NHS-POx and NU-POx to form POx-hydrogel, which promotes hemostasis.

**Synonyms:** - GATT-Patch