SKI Oncoprotein

**Semantic type:** Amino Acid, Peptide, or Protein|Biologically Active Substance

**Definition:** The c-SKI proto-oncogene encodes a transcriptional repressor that homo- and heterodimerizes with the related protein, snoN. SMAD3 associates with nuclear SKI protein in response to TGFB1 signaling, repressing transcriptional activation by SMAD3, and rendering cells resistant to the growth-inhibitory effects of TGFB. The effects of SKI can be overcome by increased expression of SMAD3. (from OMIM 164780 and NCI)

**Synonyms:** - SK Oncogene - v-SKI Protein