HER2-targeted Hypoxia-stimulated CAR T Cells

**Semantic type:** Cell|Pharmacologic Substance

**Definition:** A preparation of T-lymphocytes that have been genetically modified to express a hypoxia-stimulated chimeric antigen receptor (CAR) targeting the tumor-associated antigen (TAA) human epidermal growth factor receptor 2 (HER2; ErbB2; HER-2), with potential immunostimulating and antineoplastic activities. Upon administration, HER2-targeted hypoxia-stimulated CAR T cells target and bind to HER2-expressing tumor cells, thereby inducing selective toxicity in HER2-expressing tumor cells. HER2 is overexpressed in a variety of cancer cell types and is associated with increased tumor cell proliferation. Hypoxia-stimulated CAR may improve the expansion and survival of the CAR T cells in the hypoxic tumor microenvironment (TME).

**Synonyms:** - Anti-HER2 Hypoxia-stimulated CAR T-cells - HER2 Targeted HypoSti.CAR-T Cells - HypoSti.CAR-HER2 T Cells