pan-RAF Inhibitor TR128

**Semantic type:** Pharmacologic Substance

**Definition:** An orally bioavailable small molecule inhibitor of all members of the serine/threonine protein kinase Raf family, including A-Raf, B-Raf and C-Raf protein kinases, with potential antineoplastic activity. Upon oral administration, pan-RAF inhibitor TR128 binds to and inhibits the activity of Raf, including the BRAF V600E mutation. This prevents the activation of Raf-mediated signal transduction pathways, which may inhibit tumor cell growth. Raf protein kinases are critical enzymes in the Ras/Raf/MEK/ERK signaling pathway and are upregulated in a variety of cancer cell types. They play key roles in tumor cell proliferation and survival.

**Synonyms:** - TR 128 - TR-128 - TR128