NPM1/MLF1 Fusion Protein

**Semantic type:** Amino Acid, Peptide, or Protein

**Definition:** A fusion protein (~54 kDa) encoded by the NPM1/MLF1 fusion gene. This protein contains 175 N-terminal domain amino acid residues from the nucleophosmin protein, including its dimerization domain and a nuclear localization signal, fused in frame with the myeloid leukemia factor 1 protein (MLF1). Since the nucleophosmin-derived sequences of the NPM1/MLF1 fusion protein can promote its nuclear localization, expression of this fusion protein may result in nuclear localization of MLF1 and lead to aberrant activation of MLF1-dependent transcription factor activity, which may stimulate the differentiation of hemopoietic progenitors into myeloid cells.

**Synonyms:** - NPM-MLF1 Fusion Protein - NPM1-MLF1 Fusion Protein - NPM1::MLF1 Fusion Protein - Nucleophosmin/Myeloid Leukemia Factor 1 Fusion Protein