Gallium Ga 68 Relitegatide Brexetan

**Semantic type:** Pharmacologic Substance

**Definition:** A radiotracer composed of relitegatide brexetan, which comprises an integrin alphaVbeta6 (aVb6) binding peptide (BP), and is radiolabeled with the radionuclide gallium Ga 68, with potential integrin aVb6 imaging activity using positron emission tomography (PET). Upon administration of gallium Ga 68 relitegatide brexetan, the aVb6-binding peptide moiety selectively targets and binds to integrin aVb6-positive cancer cells. During PET, aVb6-expressing tumor cells can be visualized and the degree of tumor growth can be determined. Integrin aVb6, a cell adhesion and signaling receptor, is upregulated in certain cancer cell types and has been associated with increased proliferation, migration and invasion of tumor cells.

**Synonyms:** - 68Ga-RAD 301 - 68Ga-Trivehexin - GALLIUM GA-68 RELITEGATIDE BREXETAN - Gallium Ga 68 Trivehexin - Gallium Ga 68-labeled alphaVbeta6 Binding Peptide RAD 301 - RAD 301 - RAD-301 - RAD301 - Radiotracer RAD 301 - Trivehexin Ga-68