Atumelnant

**Semantic type:** Pharmacologic Substance

**Definition:** An orally bioavailable nonpeptide antagonist of the adrenocorticotropic hormone (ACTH) receptor (ACTHR; melanocortin receptor 2; MC2R), with potential steroid hormone production inhibitory activity. Upon oral administration, atumelnant competes with ACTH for receptor binding to MC2R in the adrenal cortex and inhibits ACTH signaling. This may inhibit the synthesis and secretion of steroid hormones. MC2R, a member of the melanocortin receptor subfamily of type 1 G protein-coupled receptors, plays a key role in adrenal steroidogenesis.

**Synonyms:** - ACTH Antagonist CRN04894 - ATUMELNANT - CRN 04894 - CRN-04894 - CRN04894 - MC2R Antagonist CRN04894