Signal Recognition Particle Ribonucleoprotein Complex

**Semantic type:** Amino Acid, Peptide, or Protein|Enzyme

**Definition:** A ribonucleoprotein complex that targets certain nascent proteins to the endoplasmic reticulum (ER) during translation. In eukaryotes, the signal recognition particle complex (SRP) recognizes the N-terminal hydrophobic signal peptide sequence on nascent peptide chains as they emerge from the ribosome. Next, the SRP slows translation and docks the complex of the ribosome and nascent peptide with the SRP receptor and translocon channel that are co-located in the membrane of the ER. Then, the SRP is released and translation elongation resumes.

**Synonyms:** - SIGNAL RECOGNITION PARTICLE - SRP - SRP - SRP Complex - SRP Ribonucleoprotein Complex - Signal Recognition Particle - Signal Recognition Particle Complex