Spectral Karyotyping

**Semantic type:** Molecular Biology Research Technique

**Definition:** A novel karyotyping procedure which is based on the simultaneous hybridization of 24 chromosome-specific painting probes labeled with different fluorochromes or fluorochrome combinations. The measurement of defined emission spectra by means of interferometer-based spectral imaging allows for the definitive discernment of all human chromosomes in different colors. (from Schrock et al., Hum Genet 1997:101:255-62)

**Synonyms:** - Color Karyotyping - Spectral Karyotype