Radium Ra 223

**Semantic type:** Element, Ion, or Isotope

**Definition:** An alpha-emitting isotope, with antineoplastic activity. Upon administration, radium Ra 223, like calcium, targets bone tissue and preferentially accumulates in osteoblastic lesions, such as those seen in areas of bone metastases, where it forms complexes with hydroxyapatite and becomes incorporated into the bone matrix. The radioisotope Ra 223 kills bone cancer cells through local emission of high energy alpha particles, causing DNA double-strand breaks and tumor regression in the skeleton. The short range effects of alpha emission allows for localized DNA damage with limited toxicity to nearby healthy bone tissue.

**Synonyms:** - RADIUM RA-223 - Ra-223 - Radium-223 - Radium-223