SARS Coronavirus 2 XBB.2.3

**Semantic type:** Virus

**Definition:** A sublineage variant of the XBB recombinant lineage of SARS coronavirus 2 where the following variations in the spike glycoprotein sequence have been identified: deletions of the amino acids at positions 25/27 and 144 and amino acid substitutions T19I, L24S, V83A, G142D, H146Q, Q183E, V213G, D253G, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, N460K, S477N, E484A, F486P, F490S, Q498R, N501Y, Y505H, P521S, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H and N969K. Also, this variant harbors a ORF1a protein amino acid substitution, G2091S.

**Synonyms:** - Omicron - SARS Coronavirus 2 Variant Lineage XBB.2.3 - SARS-CoV-2 XBB.2.3 - SARS2 XBB.2.3 - XBB.2.3