Homologous Recombination Deficiency Score

**Semantic type:** Quantitative Concept

**Definition:** The unweighted sum of three independent quantitative biomarkers of genomic instability due to homologous recombination deficiency in a sample; the markers are: loss of heterozygosity, telomeric allelic imbalance, and large-scale transitions.

**Synonyms:** - GIS Score - Genomic Instability Score - HRD Score