Autologous HPV E6/E7-targeting T-cells

**Semantic type:** Cell|Pharmacologic Substance

**Definition:** A preparation of autologous T-lymphocytes that are specifically reactive towards the human papillomavirus (HPV) viral oncoproteins E6 and E7, with potential immunomodulating and antineoplastic activities. Following leukapheresis and ex vivo priming and expansion, the autologous HPV E6/E7-targeting T-cells are re-introduced into the patient, where they target and kill tumor cells expressing these HPV tumor-associated antigens (TAAs). HPV E6 and E7 are overexpressed on certain tumor cell types and play key roles in tumor cell proliferation.

**Synonyms:** - Autologous HPV E6/E7 Reactive T Cells - Autologous HPV E6/E7-reactive T-cells - Autologous HPV-E6/E7-targeting T Cells