Gallium Ga 68 EB-ss-CPT

**Semantic type:** Pharmacologic Substance

**Definition:** A radioconjugate composed of the amphiphilic camptothecin (CPT) prodrug EB-ss-CPT, labeled with the radioisotope gallium Ga 68, with potential use as a tracer for tumor cells during positron emission tomography (PET). EB-ss-CPT is composed of CPT conjugated, via a redox-responsive disulfide linker, to an albumin-binding Evans blue (EB) derivative. Upon administration of gallium Ga 68 EB-ss-CPT, the EB-ss-CPT moiety binds to endogenous albumin and the resulting albumin-bound nanocomplex accumulates in tumor cells. This allows the detection and visualization of tumor cells upon PET imaging.

**Synonyms:** - 68Ga-EB-CPT - 68Ga-EB-ss-CPT - Gallium Ga 68-labeled CPT-ss-EB