Autologous Anti-EBV CAR T Cells BRG01

**Semantic type:** Cell|Pharmacologic Substance

**Definition:** A preparation of autologous T-lymphocytes that are genetically engineered to express a chimeric antigen receptor (CAR) targeting an Epstein-Barr virus (EBV) protein, with potential immunostimulating and antineoplastic activities. Upon intravenous administration, the autologous anti-EBV CAR T cells BRG01 targets a specific EBV protein expressed on EBV-positive cancer cells and promotes killing of these cancer cells. EBV infection is associated with various cancers and the expression of certain EBV specific proteins plays a key role in tumor cell proliferation and survival.

**Synonyms:** - Autologous Anti-EBV CAR T-cells BRG01 - Autologous Anti-EBV CAR-T Cells BRG01 - BRG 01 - BRG-01 - BRG01