Lead Pb 212 VMT-a-NET

**Semantic type:** Pharmacologic Substance

**Definition:** A radioconjugate consisting of the human somatostatin receptor subtype 2 (SSTR2)-targeting peptide and Tyr3-octreotide (TOC) analog, VMT-alpha-NET (VMT-a-NET), the N-terminus of which is conjugated via a polyethylene glycol (PEG) linker, PEG2, to a lead (Pb)-specific chelator (PSC) and bound to the alpha-emitting radioisotope lead Pb 212, with potential antineoplastic activity. Upon administration of lead Pb 212 VMT-a-NET, the peptide moiety specifically targets and binds to SSTR2, which is present on the cell membranes of many types of neuroendocrine tumors (NETs). This allows for the specific delivery of a cytotoxic dose of alpha radiation to SSTR2-positive cells. SSTR2 is overexpressed on NETs and their metastases while most normal tissues express low levels of SSTR2.

**Synonyms:** - Lead Pb 212 PSC-PEG2-TOC - Lead Pb 212 VMT-alpha-NET - [212Pb] VMT-a-NET - [212Pb]VMT-a-NET