CD3+/CD19+ Cell-depleted Autologous Hematopoietic Stem Cells

**Semantic type:** Cell|Pharmacologic Substance

**Definition:** A preparation of autologous hematopoietic stem cells (HSCs) that have been selectively depleted of CD3-positive (CD3+) T-cells and CD19-positive (CD19+) B-cells, with potential immune reconstituting activity. Upon administration, the CD3+/CD19+ cell-depleted autologous HSCs are used for autologous stem cell transplant (ASCT) and may allow for rapid and sustained engraftment and immune reconstitution without the autoreactive CD3+ T-cells and CD19+ B-cells. This may alleviate manifestations of autoimmune diseases such as systemic lupus erythematosus (SLE) and systemic sclerosis.

**Synonyms:** - Autologous CD3+/CD19+ Cell-depleted HSCs - CD3+/CD19+ Cell-depleted Autologous HSCs