IgG2

**Semantic type:** Amino Acid, Peptide, or Protein|Immunologic Factor

**Definition:** The second most abundant immunoglobulin G (IgG) subclass in the circulation of healthy individuals. The IgG2 core hinge sequence contains 12 amino acids and up to four interchain disulfide bonds. This subtype has low affinity for binding both Fc receptors and complement component C1q. The production of this IgG2 is stimulated by exposure to bacterial capsular polysaccharides and other antigenic glycans.

**Synonyms:** - Immunoglobulin G Subclass 2 - Immunoglobulin G2