12-Lipoxygenase Inhibitor VLX-1005

**Semantic type:** Pharmacologic Substance

**Definition:** A selective small molecule inhibitor of 12-lipoxygenase (12-LOX), with potential anti-platelet and anti-thrombotic activities. Upon intravenous administration, 12-LOX inhibitor VLX-1005 inhibits platelet 12-LOX. This modulates Fc gamma receptor IIa (FcgRIIa; CD32a) signaling, inhibits FcgRIIa-mediated platelet activation and aggregation, and reduces thrombus formation. The activation of the FcgRIIa receptor plays an important role in immune-mediated thrombosis, such as heparin-induced thrombocytopenia (HIT). 12-LOX, an enzyme expressed in platelets, regulates FcgRIIa activity in the platelet.

**Synonyms:** - 12-LOX Inhibitor VLX-1005 - Benzenesulfonamide, N-2-benzothiazolyl-4-(((2-hydroxy-3-methyoxyphenyl)methyl)amino)- - ML 355 - ML-355 - ML355 - N-2-benzothiazolyl-4-(((2-hydroxy-3-methoxyphenyl)methyl)amino)benzenesulfonamide - VLX 1005 - VLX-1005 - VLX-1005 - VLX1005