VGEF Mixed-Backbone Antisense Oligonucleotide GEM 220

**Semantic type:** Nucleic Acid, Nucleoside, or Nucleotide|Pharmacologic Substance

**Definition:** A mixed-backbone antisense oligonucleotide that is complementary to a pro-angiogenic vascular endothelial growth factor (VEGF) mRNA sequence. Because of its antiangiogenic properties, GEM 220 has been studied as a potential antineoplastic agent. (NCI04)

**Synonyms:** - GEM 220 - Gene Expression Modulator 220