GCK wt Allele

**Semantic type:** Gene or Genome

**Definition:** Human GCK wild-type allele is located in the vicinity of 7p13 and is approximately 55 kb in length. This allele, which encodes hexokinase-4 protein, is involved in the synthesis of hexose-6-phosphates, which are utilized in glycogen synthesis and glycolysis. Mutations in the gene are associated with permanent neonatal diabetes mellitus 1, maturity-onset diabetes of the young 2, familial hyperinsulinemic hypoglycemia 3 and late-onset noninsulin-dependent diabetes mellitus.

**Synonyms:** - FGQTL3 - GK - GLK - Glucokinase (Hexokinase 4) Gene - Glucokinase wt Allele - HHF3 - HK4 - HKIV - HXKP - Hexokinase 4 Gene - Hexokinase D, Pancreatic Isozyme Gene - LGLK - Liver Glucokinase Gene - MODY2 - Maturity Onset Diabetes of the Young 2 Gene - PNDM1