Bifunctional UDP-N-Acetylglucosamine 2-Epimerase/N-Acetylmannosamine Kinase

**Semantic type:** Amino Acid, Peptide, or Protein|Enzyme

**Definition:** Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (722 aa, ~79 kDa) is encoded by the human GNE gene. This protein is involved in both the hydrolysis of UDP-N-acetyl-alpha-D-glucosamine yielding N-acetyl-D-mannosamine and the phosphorylation of N-acyl-D-mannosamine yielding N-acyl-D-mannosamine 6-phosphate.

**Synonyms:** - EC 3.2.1.183/EC 2.7.1.60 - GNE - UDP-GlcNAc-2-Epimerase/ManAc Kinase - UDP-N-Acetylglucosamine 2-Epimerase/N-Acetylmannosamine Kinase - UDP-N-Acetylglucosamine-2-Epimerase/N-Acetylmannosamine Kinase