HEXA wt Allele

**Semantic type:** Gene or Genome

**Definition:** Human HEXA wild-type allele is located in the vicinity of 15q23 and is approximately 35 kb in length. This allele, which encodes beta-hexosaminidase subunit alpha protein, plays a role in 3-beta hexosaminidase activity. Mutation of the gene is associated with Tay Sachs disease and other forms of GM2-related gangliosidosis.

**Synonyms:** - GM2 Gangliosidosis Gene - Hexosaminidase Subunit Alpha wt Allele - TSD - Tay Sachs Disease Gene