Allogeneic CD19/CD20-specific CAR-T Cells P-CD19CD20-ALLO1

**Semantic type:** Cell|Pharmacologic Substance

**Definition:** An off-the-shelf (OTS) preparation of human allogeneic T-lymphocytes containing primarily stem cell memory T-cells (Tscm) that have been genetically modified to express two chimeric antigen receptors (CARs) targeting the tumor-associated antigens (TAAs) CD19 and CD20, with potential immunostimulating and antineoplastic activities. Upon administration, allogeneic CD19/CD20-specific CAR-T cells P-CD19CD20-ALLO1 specifically recognize and induce selective toxicity in CD19- and/or CD20-expressing tumor cells. Both CD19 and CD20 are B-cell-specific cell surface antigens overexpressed in B-cell lineage malignancies. Targeting both CD19 and CD20 may prevent tumor cell antigen escape and relapse.

**Synonyms:** - Allogeneic Anti-CD19/Anti-CD20 CAR T Cells P-CD19CD20-ALLO1 - Allogeneic T Stem Cell Memory CAR-T Cells P-CD19CD20-ALLO1 - Allogeneic Tscm CAR-T Cells P-CD19CD20-ALLO1 - P-CD19CD20-ALLO 1 - P-CD19CD20-ALLO-1 - P-CD19CD20-ALLO1