IPO8 wt Allele

**Semantic type:** Gene or Genome

**Definition:** Human IPO8 wild-type allele is located in the vicinity of 12p11.21 and is approximately 67 kb in length. This allele, which encodes importin-8 protein, is involved in nuclear cargo import. Mutation of the gene is associated with vascular aneurysm, immune dysregulation, skeletal anomalies, and skin and joint laxity (VISS) syndrome.

**Synonyms:** - IMP8 - Importin 8 wt Allele - RAN Binding Protein 8 Gene - RANBP8 - VISS