Autologous Anti-CDH17 CAR-T Cells CHM-2101

**Semantic type:** Cell|Pharmacologic Substance

**Definition:** A preparation of autologous T-lymphocytes transduced with a lentiviral vector expressing a chimeric antigen receptor (CAR) targeting the tumor-associated antigen (TAA) cadherin-17 (CDH17), with potential immunomodulatory and antineoplastic activities. After isolation, transduction, and expansion in culture, the autologous anti-CDH17 CAR-T cells CHM-2101 are reintroduced into the patient and are directed to tumor cells expressing CDH17, which may result in a selective toxicity against, and lysis of CDH17-expressing tumor cells. CDH17, a cell surface adhesion protein, is overexpressed in a variety of cancer cell types.

**Synonyms:** - Autologous Anti-CDH17 CAR T Cells CHM-2101 - Autologous Anti-CDH17 CAR T-cells CHM-2101 - Autologous Anti-cadherin-17 CAR-T Cells CHM-2101 - CDH17 CAR T Cells CHM-2101 - CHM 2101 - CHM-2101 - CHM2101