Allogeneic Anti-CD33 CAR T-cells VCAR33

**Semantic type:** Cell|Pharmacologic Substance

**Definition:** A preparation of allogeneic T-lymphocytes, derived from the same matched healthy donor who provided a stem cell transplant and transduced with a lentiviral vector to express a chimeric antigen receptor (CAR) specific for the CD33 antigen, with potential immunomodulating and antineoplastic activities. Upon administration, allogeneic anti-CD33 CAR T-cells VCAR33 specifically recognize and kill CD33-expressing tumor cells. CD33 is expressed on normal non-pluripotent hematopoietic stem cells and is overexpressed on myeloid leukemia cells.

**Synonyms:** - Allogeneic Anti-CD33 CAR-T Cells VCAR33 - Donor-Derived Anti-CD33 CAR T Cells VCAR33 - VCAR 33 - VCAR-33 - VCAR33