Autosomal Recessive Cerebral Arteriopathy with Subcortical Infarcts and Leukoencephalopathy

**Semantic type:** Disease or Syndrome

**Definition:** An autosomal recessive condition caused by mutation(s) in the HTRA1 gene, encoding serine protease HTRA1. It is characterized by subcortical infarcts and leukoencephalopathy resulting in progressive motor dysfunction and dementia.

**Synonyms:** - CARASIL