Juvenile Trabecular Ossifying Fibroma

**Semantic type:** Neoplastic Process

**Definition:** A rare, benign fibro-osseous neoplasm that usually affects the jaws and predominantly arises in children and adolescents. It is characterized by prominent osteoid formation rimmed by osteoblasts in a fibrotic stroma. Patients usually present with painless jaw expansion that is associated with rapid growth and tooth displacement. Amplifications of MDM2 and RASAL1 genes have been detected in some cases. Recurrences have been reported in a minority of cases.

**Synonyms:** - JTOF - Trabecular Juvenile Ossifying Fibroma - Trabecular Ossifying Fibroma