Autologous TROP2-CAR-transduced PD-1-positive T Cells T60c

**Semantic type:** Cell|Pharmacologic Substance

**Definition:** A preparation of autologous programmed cell death protein 1 (PD-1; PDCD1; CD279)-positive T-lymphocytes transduced with a lentivirus expressing a chimeric antigen receptor (CAR) specific for the tumor-associated antigen (TAA) trophoblast cell surface protein 2 (trophoblast antigen 2; tumor-associated calcium signal transducer 2; TROP2; TROP-2; TACSTD2; GA733-1; M1S1), with potential immunostimulating and antineoplastic activities. Upon administration, autologous TROP2-CAR-transduced PD-1-positive T-cells T60c target, bind to and induce selective cytotoxicity in TROP2-expressing tumor cells. TROP2 is a transmembrane protein overexpressed in various tumors. Its expression is associated with enhanced tumor aggressiveness, metastasis, drug resistance and increased tumor cell survival.

**Synonyms:** - T 60c - T-60c - T60c - TROP2-CAR-transduced PD-1-positive T-cells T60c