HIF-2alpha Inhibitor HS-10516

**Semantic type:** Pharmacologic Substance

**Definition:** An orally bioavailable inhibitor of hypoxia inducible factor (HIF)-2alpha, with potential antineoplastic activity. Upon oral administration, HIF-2alpha inhibitor HS-10516 targets and binds to HIF-2alpha, thereby preventing HIF-2alpha heterodimerization and its subsequent binding to DNA. This results in decreased transcription and expression of HIF-2alpha downstream target genes, many of which regulate tumor cell growth and survival. Blocking HIF-2alpha reduces the proliferation of HIF-2alpha-expressing tumor cells. HIF-2alpha, a heterodimeric transcription factor overexpressed in many cancer cell types, promotes proliferation, progression and metastasis of tumors.

**Synonyms:** - HIF-2-alpha Inhibitor HS-10516 - HIF2-alpha Inhibitor HS-10516 - HIF2a Inhibitor HS-10516 - HIF2alpha Inhibitor HS-10516 - HS 10516 - HS-10516 - HS10516