KRAS Inhibitor BI 3706674

**Semantic type:** Pharmacologic Substance

**Definition:** An orally bioavailable small molecule inhibitor that targets the oncogenic KRAS wild-type (WT) and various KRAS mutant forms, such as KRAS G12C, with potential antineoplastic activity. Upon oral administration, KRAS inhibitor BI 3706674 selectively binds to KRAS, thereby inhibiting KRAS-dependent signaling and inhibits growth and survival of KRAS-overexpressing and mutated tumor cells. KRAS, a member of the RAS family of oncogenes, serves an important role in cell signaling, division and differentiation. Mutations of KRAS may induce constitutive signal transduction leading to tumor cell growth, proliferation, invasion, and metastasis.

**Synonyms:** - BI 3706674 - BI-3706674 - BI3706674